PROBLEM TO BE SOLVED: To provide a method of sterilizing a pure water production apparatus for pharmaceuticals capable of improving the hot water sterilizing efficiency and of ultimately inhibiting effects exerted onto an electric deionizer at the time of a hot water sterilizing treatment and a pure water production apparatus for pharmaceuticals.SOLUTION: A provided method of sterilizing a pure water production apparatus is a method of sterilizing a pure water production apparatus furnished not only with a pump, a heat exchanger, a reverse osmotic membrane device, and an electric deionizer in proper order along a treatment line connecting a raw water tank and a pure water tank or use point but also with circulatory lines connecting, to the raw water tank via ON-OFF valves, the respective outlet-side pipelines of the reverse osmotic membrane device and the electric deionizer wherein hot water is circulated through the treatment line and the circulatory lines, wherein concentrated water within the reverse osmotic membrane device is subsequently discharged out of the system while non-heated raw water is being fed into the raw water tank, and wherein the non-heated raw water is circulated through the treatment line and the circulatory lines.COPYRIGHT: (C)2014,JPO&INPIT【課題】熱水殺菌効率を向上させるとともに、熱水殺菌処理時の電気脱イオン装置への影響を極力抑える医薬品用の純水製造装置の殺菌方法及び医薬品用の純水製造装置を提供すること。【解決手段】原水タンクと純水タンク又はユースポイントとを結ぶ処理ラインに沿って、ポンプ、熱交換器、逆浸透膜装置及び電気脱イオン装置とを順に備えるとともに、前記逆浸透膜装置及び前記電気脱イオン装置の各出口側配管と前記原水タンクとを開閉バルブを介して接続する循環ラインを備えた純水製造装置の殺菌方法であって、熱水を前記処理ライン及び前記循環ラインに循環させた後に、非加熱の原水を前記原水タンクに供給しつつ前記逆浸透膜装置の濃縮水を系外に排出して前記非加熱の原水を前記処理ライン及び前記循環ラインに循環させる純水製造装置の殺菌方法。【選択図】図1
