HOLLICK, JONATHAN JAMES,JONES, STUART DONALD,FLYNN, CLAIRE JUNE,THOMAS, MICHEAL GEORGE
申请号：
CA2700979
公开号：
CA2700979C
申请日:
2008.09.29
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to a compound of formula (VII)I, or apharmaceutically acceptable salt or ester thereofwherein: X is NR7； Y is O or N-(CH2)n R19 ； n is 1, 2 or 3； m is 1 or 2； R1and R2 are each independently H, alkyl or cycloalkyl； R4and R4' are each independently H or alkyl； or R4 and R4' together form a spirocycloalkyl group； R19 is H, alkyl, aryl or a cycloalkylgroup； R6 is OR8 or halogen； and R7 and R8 are each independently H or alkyl.Further aspects relate to pharmaceutical compositionscomprising said compounds and use therefore in the treatment of proliferativedisorders and the like.
