A fully human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human angiopoietin-like protein 4 (hANGPTL4) is provided. The human anti-hANGPTL4 antibodies are useful in treating diseases or disorders associated with ANGPTL4, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, chylomicronemia, and so forth. Furthermore, the anti-hANGPTL4 antibodies can be administered to a subject in need thereof to prevent or treat diseases or disorders, for which abnormal lipid metabolism is a risk factor. Such diseases or disorders include cardiovascular diseases, such as atherosclerosis and coronary artery diseases； acute pancreatitis； nonalcoholic steatohepatitis (NASH)； diabetes； obesity； and the like.提供一個專一性結合及抑制人類類血管生成素蛋白4(hANGPTL4)之完全人類抗體或抗原結合片段，該人類抗人類類血管生成素蛋白4抗體被用於治療與人類類血管生成素蛋白4相關之疾病或失調，諸如：高血脂症、高脂蛋白血症及異常血脂症，包括：高三酸甘油脂血症、高膽固醇血症、高乳糜微粒血症...等，此外，該抗人類類血管生成素蛋白4抗體可被施用於有其需要之患者，以預防或治療疾病或失調，異常的脂質代謝對其係一種危險因素，此疾病或失調包括心血管疾病，諸如：動脈粥狀硬化及冠狀動脈疾病、急性胰臟炎、非酒精性脂肪性肝炎(NASH)、糖尿病、肥胖症及諸如此類之疾病。
