MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
发明人:
MATHEUS, SUSANNE,MAHLER, HANNS-CHRISTIAN
申请号：
CA2547446
公开号：
CA2547446C
申请日:
2004.11.12
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to solid forms of antibodies against the EGF receptor,especially precipitates and crystals of monoclonal antibodies against the EGFreceptor,especially preferably Mab C225 (Cetuximab) and Mab h425 (EMD 72000), thatcreatebiologically active antibody proteins by dissolution or suspension in anaqueous medium.Said proteins can be obtained by precipitation of the antibody dissolved orsuspended inthe aqueous medium and/or one of the variants or fragments thereof by means ofaprecipitation reagent. The invention also relates to pharmaceuticalpreparationscontaining at least one solid form of the cited antibody in a precipitated non-crystallineform, a precipitated crystalline form or a soluble or suspended form, andoptionallycarrier and/or auxiliary substances and/or other pharmaceutical activeingredients, and toa method for producing inventive solid forms of anti-EGFR-antibodies.
