Sarah Fredriksson,Sylvia Koivunen,Fredrik Olsson,Hanna-Karin Toftevall
申请号：
US11990522
公开号：
US08557289B2
申请日:
2006.08.21
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A nano sized particle for in vitro or ex vivo biomolecule delivery to cell cultures through heat induced endosomal release comprising a superparamagnetic core coated in a heat sensitive coating, comprising membrane disruptive components and binding sites for attachment of biomolecules and markers to be delivered is provided. A method is provided for introducing the release effect of a plurality of said biomolecule and endosomal disrupture molecules by applying an alternating field to a cell culture harboring the particle described by the invention.
