Compounds 4 - carboxamido - isoindolinona, Selective inhibitors of parp-1； Preparation Process； a Pharmaceutical composition； in vitro method； product； and their use as a Medicine with antineoplastic activity
There are provided substituted 4-carboxamido-isoindolinone derivatives which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-I with respect to poly (ADP-ribose) polymerase P ARP-2. The compounds of this invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of in-flammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.<；p>；Compuestos derivados de 4-carboxamido-isoindolinona, inhibidores selectivos de PARP-1； proceso de preparació；n； composició；n famacé；utica； un mé；todo in vitro； combinació；n farmacé；utica, y su uso como medicamento con actividad antineoplá；sica<；/p>；
