COMPOSITIONS ET PROCÉDÉS DE RÉGULATION DE L'ACTIVITÉ DE L'INHIBITEUR DE LA PROTÉINE DE LIAISON À L'ADN DE TYPE 2 (ID2)

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专利权人:

The Trustees of Columbia University in the City of New York

发明人:

申请号：

EP17736345.4

公开号：

EP3400003A4

申请日:

2017.01.05

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

The present disclosure provides, in one embodiment, a method of treating or preventing an ID2 protein-related disease in a patient at risk of developing or having such a disease by administering to the patient a composition in an amount and for a time sufficient to increase degradation of HIFα in a cell affected by the ID2 protein-related disease in the patent and/or to decrease half-life of HIFα in the cell affected by the ID2 protein-related disease in the patient, as compared to an untreated cell affected by the ID2 protein-related disease.

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