A method of guiding a catheter during a treatment procedure includes acquiring scan data of a patient volume in position for the treatment procedure, registering volume data of the patient volume to the scan data, acquiring fluoroscopic data for the patient volume during the treatment procedure, and generating a volume representation of the fluoroscopic data during the treatment procedure. Generating the volume representation includes superimposing the fluoroscopic data on the volume data based on the registering. The volume representation of the fluoroscopic data is displayed, the volume representation showing a position of a mitral valve clip carried by the catheter relative to the patient volume.
