A method for interventional navigation using 3D contrast-enhanced ultrasound (CEUS) imaging (10) includes acquiring a reference 3D CEUS volume and tracking information for a desired portion of an anatomy (22) subject to an interventional procedure with an instrument (40), during a useful lifetime of a contrast enhancement agent administered to the anatomy. Real-time tracked tissue images (38) are acquired during the interventional procedure. In addition, a corresponding CEUS multiplanar reconstruction (MPR) (44) for at least one of the acquired real-time tracked tissue images is generated. At least one of the acquired real-time tracked tissue images is displayed (20) along with the corresponding CEUS MPR. The displayed real-time tracked tissue image includes at least an image of the instrument within the desired portion of the anatomy and the CEUS MPR corresponds to the displayed real-time tracked tissue image. The CEUS MPR image includes a contrast enhanced MPR image obtained from the reference 3D CEUS volume and includes a target volume of interest (46), thereby providing a concurrent display of contrast enhanced image information and tissue image information useful for the interventional navigation at least subsequent to the expiration of the contrast enhancement useful lifetime.Cette invention concerne un procédé de navigation interventionnelle par imagerie ultrasonore 3D (CEUS) avec injection de contraste (10), lequel procédé consiste à acquérir un volume CEUS 3D de référence et à poursuivre des informations relatives à une portion anatomique (22) souhaitée subissant une intervention au moyen dun instrument (40), pendant une durée de vie utile dun agent de contraste administré au corps. Les images (38) des tissus poursuivie en temps réel sont acquises pendant lintervention. En outre, une reconstitution multiplan (MPR) CEUS correspondante (44) pour au moins lune des images des tissus poursuivies en temps réel est générée. Au moins lune des images des tissus pour
