REDEY, STEPHANE,BUCHMANN, STEPHAN,BONARD, JEAN MICHEL,WOINET, BERTRAND
申请号：
CA2583845
公开号：
CA2583845C
申请日:
2005.10.11
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl~-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined andnon-hygroscopic sulfate salt and a process for its preparation. Further, thepresent invention relates to the use of said 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-~quinolin-4-yl)-urea as a crystalline,stoichiometrically defined and non-hygroscopic sulfate salt alone or incombination with other compounds. Further, the present invention relates toformulations of said 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)~ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined andnon-hygroscopic sulfate salt in the preparation of pharmaceuticalcompositions. The invention also relates to the use of such sulfate salts informulations as neurohormonal antagonists.
