Jamie M. Orengo,Andrew J. Murphy,Ashok T. Badithe,Vishal Kamat,Yashu Liu
申请号：
US15994294
公开号：
US20180346555A1
申请日:
2018.05.31
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are antibodies that bind Fagales allergens, Fagales related allergens, birch pollen, or Bet v 1, compositions comprising the antibodies, nucleic acids encoding the antibodies, and methods of using the antibodies. According to certain embodiments, the antibodies are fully human monoclonal antibodies that bind to Bet v 1. The antibodies are useful for binding Bet v 1 in vivo, thus preventing binding of the allergen to pre-formed IgE on the surface of mast cells or basophils. In doing so, the antibodies act to prevent the release of histamine and other inflammatory mediators from mast cells and/or basophils, thus ameliorating the untoward response to the Fagales allergens in sensitized individuals.
