Tomas Hudlicky,Robert James Carroll,Hannes Leisch,Ales Machara,Lukas Werner,Mary Ann Endoma-Arias
申请号：
US14609612
公开号：
US09340550B2
申请日:
2015.01.30
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides a method for the N-demethylation and N-functionalization of an N-methylated heterocycle such as a morphine alkaloid or tropane alkaloid. The method comprises reacting the heterocycle with an functionalization agent in the presence of a transition metal catalyst in air or in the presence of an oxidant.
