mitigation and reversal of fibrosis and inflammation through inhibition of tl1a function and related signaling pathways

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专利权人:

CEDARS-SINAI MEDICAL CENTER

发明人:

Dalin LI,David Q. SHIH,Janine BILSBOROUGH,Stephan R. TARGAN

申请号：

BR112015024752

公开号：

BR112015024752A2

申请日:

2014.03.27

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

Patent for: â € œmitigation and reversal of fibrosis and inflammation through inhibition of tl1 function and signaling pathwaysâ €. The invention relates to methods of treating fibrosis and inflammatory bowel disease. In one embodiment, the present invention treats inflammation of the intestine by administering a therapeutically effective dosage of t1a inhibitors and / or dr3 inhibitors to an individual. In another embodiment, the present invention provides a method for reversal of tissue fibrosis in an individual by inhibiting the signaling function of tl1a. dr3.patente de invenã§ã£o para: “mitigaã‡ãƒo e reversãƒo da fibrose e inflamaã‡ãƒo atravã‰s da inibiã‡ãƒo da funã‡ãƒo de tl1a e vias de sinalizaã‡ãƒo relacionadasâ€�. a invenã§ã£o refere-se a mã©todos de tratamento da fibrose e doenã§a inflamatã³ria do intestino. em uma modalidade, a presente invenã§ã£o trata a inflamaã§ã£o do intestino atravã©s da administraã§ã£o de uma dosagem terapeuticamente eficaz de inibidores do tl1a e/ou inibidores de dr3 a um indivã­duo. em outra modalidade, a presente invenã§ã£o fornece um mã©todo de reversã£o da fibrose tecidual em um indivã­duo atravã©s da inibiã§ã£o da funã§ã£o de sinalizaã§ã£o de tl1a-dr3.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/