COMPOSITION POUR LA PRÉVENTION OU LE TRAITEMENT DU CANCER SOLIDE COMPRENANT UN COMPOSÉ INHIBANT LA LIAISON DE AIMP2-DX2 ET DE K-RAS ET NOUVEAU COMPOSÉ INHIBANT LA LIAISON DE AIMP2-DX2 ET K-RAS
연세대학교 산학협력단;INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY;MEDICINAL BIOCONVERGENCE RESEARCH CENTER;재단법인 의약바이오컨버젼스연구단
发明人:
KWON, Nam Hoon,권남훈,KIM, Sunghoon,김성훈,HAN, Gyoonhee,한균희,HAN, Jung Min,한정민,LEE, Chulho,이철호
申请号:
KRKR2019/006910
公开号:
WO2019/235894A1
申请日:
2019.06.07
申请国别(地区):
KR
年份:
2019
代理人:
摘要:
The present invention relates to a composition for preventing or treating solid cancer comprising a compound inhibiting the binding of AIMP2-DX2 and K-Ras and a novel compound inhibiting the binding of AIMP2-DX2 and K-Ras. The compound represented by formula 1 according to the present invention inhibits the binding of AIMP2-DX2 and K-Ras, thereby having very superior effects of lowering the level of K-Ras protein in cancer cells and inhibiting the occurrence and progression of cancer. Thus, the compound can be very useful for the prevention or treatment of solid cancer overexpressing AIMP2-DX2.La présente invention concerne une composition pour prévenir ou traiter un cancer solide comprenant un composé inhibant la liaison de AIMP2-DX2 et de K-Ras et un nouveau composé inhibant la liaison de AIMP2-DX2 et K-Ras. Le composé représenté par la formule 1 selon la présente invention inhibe la liaison de AIMP2-DX2 et de K-Ras, ayant ainsi des effets très supérieurs d'abaissement du niveau de protéine K-Ras dans des cellules cancéreuses et d'inhibition de l'apparition et de la progression du cancer. Ainsi, le composé peut être très utile pour la prévention ou le traitement du cancer solide surexprimant AIMP2-DX2.본 발명은 AIMP2-DX2와 K-Ras의 결합을 저해하는 화합물을 포함하는 고형암 예방 또는 치료용 조성물 및 AIMP2-DX2와 K-Ras의 결합을 저해하는 신규 화합물에 관한 것이다. 본 발명에 따른 상기 화학식 1로 표시되는 화합물은 AIMP2-DX2와 K-Ras의 결합을 저해하여 암 세포에서 K-Ras 단백질의 수준을 낮추고 암의 발생과 진행을 억제하는 효과가 매우 우수하므로, AIMP2-DX2를 과발현하는 고형암의 예방 또는 치료에 매우 유용하게 활용이 될 수 있다.