The Government of the United States of America as Represented by the Secretary of the Departme
发明人:
Brad St. Croix,Steven Seaman
申请号：
US13863674
公开号：
US20130202528A1
申请日:
2013.04.16
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Methods of inhibiting pathological angiogenesis in a subject are disclosed. In particular examples, the method includes administering a therapeutically effective amount of a composition to a subject wherein the composition includes a specific binding agent that preferentially binds to one or more pathological angiogenesis marker proteins including Vscp, CD276, ETSvg4 (Pea3), CD137 (4-1BB), MiRP2, Ubiquitin D (Fat10), Doppel (prion-PLP), Apelin, Plgf, Ptpm (IA-2), CD109, Ankylosis, and collagen VIIIα1. In additional examples, methods to deliver a therapeutic agent to a brain or liver endothelial cell are also disclosed.
