The present invention relates to substituted indazole compounds, their pharmaceutically acceptable salts, and their isomers, steroisomers, atropisomers, conformers, tautomers, polymorphs, hydrates or solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above mentioned compounds for the preparation of medicament for use as pharmaceuticals.本發明係相關於經取代吲唑化合物,其藥學上可接受的鹽類及其異構物、立體異構物、構型異構(atropisomers)、構型異構物(conformers)、互變異構物、多型體、水合物以及溶劑化物。本發明亦包含該化合物之藥學上可接受的組成物與製備此新穎化合物的方法。本發明進一步地相關於上述化合物在作為藥劑使用之藥品製備的用途。