SHAW, WENDY J.,YONKER, CLEMENT R.,FULTON, JOHN L.,TARASEVICH, BARBARA J.,MCCLAIN, JAMES,TAYLOR, DOUG,MATSON, DEAN W.
申请号：
CA2748273
公开号：
CA2748273C
申请日:
2009.12.28
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
A medical implant device having a substrate with an oxidized surface and asilane derivative coating covalentlybonded to the oxidized surface. A bioactive agent is covalently bonded to thesilane derivative coating. An implantable stentdevice including a stent core having an oxidized surface with a layer ofsilane derivative covalently bonded thereto. A spacer layercomprising polyethylene glycol (PEG) is covalently bonded to the layer ofsilane derivative and a protein is covalently bonded tothe PEG. A method of making a medical implant device including providing asubstrate having a surface, oxidizing the surfaceand reacting with derivitized silane to form a silane coating covalentlybonded to the surface. A bioactive agent is then covalentlybonded to the silane coating. In particular instances, an additional coatingof bio- absorbable polymer and/ or pharmaceuticalagent is deposited over the bioactive agent.
