An auto-disable syringe is provided. The auto-disable syringe includes an injection tube connected to a needle seat and an injection needle connected to an auto-disable member. The auto-disable member connected to the injection needle is disposed on the needle seat. The injection tube is internally provided with a stopper and a hollow push tube. The push tube is internally provided with a spring seat accommodated by a spring and a stop block. A lower end of the auto-disable member is provided with a hook, and an upper end of the spring seat is provided with a hook groove for fastening with the hook. A cartridge is accommodated between the push tube and the spring seat. An upper part of the cartridge is accommodated by the stopper, and a lower part of the cartridge is abutted by one end of the spring in a compressed state.