Владимир ЦМИЛЯНОВИЦ (CH),Натаса ЦМИЛЯНОВИЦ (CH),Бернд ГИЗЕ (CH),Маттиас ВИМАНН (CH)
申请号：
RU2012151201/04
公开号：
RU2012151201A
申请日:
2011.04.27
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. The compound of formula (I) in which R represents methyl, n-hexyl, aminoethyl, methylaminoethyl, ethylaminoethyl, dimethylaminoethyl, acryloylaminoethyl, methacryloylaminoethyl, methoxyethyl, ethoxyethyl, C-C-alkylsulfonyl, acryloyl or methacrylo； or R is aminoethyl, acryloyl or acryloylaminoethyl having a linker and a tag, and R and R, independently of one another, are hydrogen or C-Calkyl or R and R together form an ethylene bridge； and tautomers, solvates and their pharmaceutically acceptable salts. 2. The compound of formula (I) according to claim 1, wherein R is methyl, n-hexyl, 2-aminoethyl, 2- (methylamino) ethyl, 2- (ethylamino) ethyl, 2- (acryloamino) ethyl, 2-methoxyethyl, 2-ethoxyethyl , C-C-alkylsulfonyl, acryloyl or methacryloyl. 3. The compound of formula (I) according to claim 1, wherein R is 2-aminoethyl, acryloyl or 2- (acryloylamino) ethyl, each with a linker and a label. The compound of formula (I) according to claim 1, wherein R is methyl, 2-aminoethyl, 2- (acryloylamino) ethyl, 2-ethoxyethyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, acryloyl or methacryloyl. 5. The compound of formula (I) according to claim 1, wherein R is methyl, 2-aminoethyl, 2- (acryloylamino) ethyl, 2-ethoxyethyl, methylsulfonyl, ethylsulfonyl or acryloyl. The compound of formula (I) according to claim 1, wherein R is methyl, 2- (acryloylamino) ethyl, methylsulfonyl or acryloyl. A compound of formula (I) according to claim 1, wherein R is 2-aminoethyl or acryloyl, each having a linker and a label selected from biotin, fluorophore or a polymer bead. The compound of formula (I) according to any one of claims 1 to 7, in which R and R, independently of one another, are hydrogen, methyl, ethyl or isopropyl, or R and R together form a methylene or ethylene bridge. The compound of formula (I) according to any one of claims 1 to 7, in which R and Roba �1. Соединение формулы (I)в которойRозначает метил, н-гексил, аминоэтил, метиламиноэтил, этиламиноэтил, диметиламиноэтил,
