Various embodiments include methods of diagnosing susceptibility to epilepsy in an individual or methods of managing treatment of a neurological condition in an individual, comprising: obtaining a sample from the individual assaying the sample to determine the presence or absence of one or more biomarkers of epilepsy and diagnosing susceptibility to epilepsy in the individual based on the presence of one or more biomarkers of epilepsy. Various embodiments further include kits for diagnostic use, comprising a diagnostic panel of one or more of the biomarkers: Let-7d-5p, miR-340-3p, miR-484, miR-151, miR-350, miR-770-5p, miR-139-3p, miR-2985, miR-101a-5p, miR-206-3p, miR-760-3p, miR-383-5p, miR-294, and miR-328a-5p.
