This invention relates to an implantable flexible neural probe for long-term brain neural signal recording and deep brain electro-stimulation and its manufacturing method. The implantable flexible neural probe for long-term brain neural signal recording and deep brain electro-stimulation comprises a body part and an impact-resistant material layer. The body part covers the impact-resistant material layer, and the deformation resistance of the impact-resistant material layer is greater than that of the body part. The body part has a rear end and a needle-like front end, respectively provided with the same amount of plural micro-electrode parts for signal transmission. Therefore, this invention provides the benefits and effects of long-term multi-point signal recording and stimulation, better strength, good biocompatibility, good signal recording quality and high electro-stimulation tolerance.本發明係為一種用於長時間腦部神經信號記錄與深層腦部電刺激之植入式可撓性神經探針及其製法,其用於長時間腦部神經信號記錄與深層腦部電刺激之植入式可撓性神經探針係包括一本體部及一耐衝擊材料層。該本體部係包覆該耐衝擊材料層,且該耐衝擊材料層之耐變形力係大於該本體部之耐變形力;該本體部係具有一後端及一針狀前端,分別設有具有數量相同之複數微電極部,用以進行訊號之傳輸;故,本發明兼具可長時間多點信號記錄與刺激、強度較佳、生物相容性佳、記錄信號品質佳及高電刺激耐受力等優點及功效。52‧‧‧本體第一階段加工步驟53‧‧‧耐衝擊加工步驟54‧‧‧本體第二階段加工步驟55‧‧‧微電極層製作步驟56‧‧‧蝕刻步驟57‧‧‧本體第三階段加工步驟58‧‧‧微電極完成步驟59‧‧‧佈線步驟
