SMALL MOLECULES BLOCKING HISTONE READER DOMAINS

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专利权人:

发明人:

GROTH ANJA,SAREDI GIULIA,HUANG HONGDA,HAMMOND COLIN,PATEL DINSHAW

申请号：

IN201817013779

公开号：

IN201817013779A

申请日:

2018.04.11

申请国别(地区):

IN

年份:

2018

代理人:

摘要：

The present invention relates to small molecules interfering with the conformational space of the TONSL ARD occupied by the histone H4 tail. These small molecules targets the binding pocket ofTONSL encompassing the H4 residues Kl2- R23 and act by preventing or disrupting the binding of the H4 tail Kl2- R23 with the TONSL ARD via direct competition or via allosteric disruption of the binding pocket. The present inventors have identified and solved the structure of a histone reader domain ofTONSL termed the ARD (ankyrin repeat domain).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/