The present invention provides an emergency supply valve to support the in situ administration of a drug to a subject in need thereof, comprising an infusion needle connected to a movable piston, wherein said piston is forwarded by infusion solution unable to pass the regular drug line due to kinking or obstruction thereof, a self-sealing membrane that is disrupted by the infusion needle when the piston is in a forward position, a connecting unit that connects the needle to the regular drug conduit when the needle is in a forward position, and a pressure sensitive mechanism that retracts the piston from the forward position when an increased pressure of the drug supply is normalized and its use for the treatment of subjects in need thereof.Mevcut buluş, Formül I: Bileşimi veya bunun farmasötik olarak kabul edilebilir tuzlarının yanı sıra, Janus kinaz (JAK) aktivitesini inhibe eden ve örneğin inflamatuar bozukluklar, otoimmün bozukluklar, kanser ve başka hastalıkları kapsayan, JAK aktivitesiyle ilgili hastalıkların tedavisinde faydalı olan bipirazol türevlerinin yanı sıra bunların bileşimleri ve kullanım metotlarını sağlamaktadır.
