FVII or FVIIa variants having increased clotting activity

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专利权人:

Bayer HealthCare LLC

发明人:

Andersen, Kim Vilbour,Haaning, Jesper Mortensen

申请号：

AU2014253469

公开号：

AU2014253469A1

申请日:

2014.10.21

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

#$%^&*AU2014253469A120141113.pdf#####FVII OR FVIIA VARIANTS HAVING INCREASED CLOTTING ACTIVITY ABSTRACT The present invention relates to novel Factor VII or VIa variants comprising a substitution in at least one position selected from the group consisting of L39, 142, S43, K62, L65, F71, E82 and F275. Such variants exhibit increased clotting activity as compared to human wild-type Factor VIa. The present invention also relates to use of such Factor VII or VIa variants in therapy, in particular for the treatment of a variety of coagulation-related disorders.

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