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ORGANOSULFUR COMPOUNDS, A METHOD OF MAKING ORGANOSULFUR COMPOUNDS AND THEIR USE FOR INHIBITING THE GROWTH OF TUMOUR CELLS
专利权人:
UNIVERSITY OF CAPE TOWN
发明人:
KASCHULA, CATHERINE, HART,HUNTER, ROGER,PARKER, MOHAMED, IQBAL
申请号:
EP09804634
公开号:
EP2321271A4
申请日:
2009.08.05
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
Organosulfur compounds of the general formula (2) are described, wherein R1 and R2 are linear or branched C1-C5 alkyl linear or branched C1-C5 alkenyl with the proviso that R1 is not prop-1-enyl (allyl) substituted linear or branched C1-C5 alkenyl or substituted linear or branched C1-C5 alkyl, in which the substituents are selected from OR3, NR4R5, COOR6, CON-R7R8, in which R3 is selected from H, COR9, para-methoxybenzyl and trialkylsilyl, in which R9 is alkyl or substituted alkyl R4 N and R5 are alkyl or R4 and R5 together form a phthalimido group R6 is alkyl or substituted alkyl and R7 and R8 are alkyl or substituted alkyl substituted or unsubstituted aromatic specifically where R1 and R2 are benzyl, para-methoxybenzyl and/or ortho,para-methoxybenzyl and substituted or unsubstituted heteroaromatic. The compounds can be used for inhibiting the growth of tumor cells and for treating cancer. A pharmaceutical composition and a method of preparing the compounds are also described.
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