A Multiple Aperture Ultrasound Imaging system and methods of use are provided with any number of features. In some embodiments, a multi-aperture ultrasound imaging system is configured to transmit and receive ultrasound energy to and from separate physical ultrasound apertures. In some embodiments, a transmit aperture of a multi-aperture ultrasound imaging system is configured to transmit an omni-directional unfocused ultrasound waveform approximating a first point source through a target region. In some embodiments, the ultrasound energy is received with a single receiving aperture. In other embodiments, the ultrasound energy is received with multiple receiving apertures. Algorithms are described that can combine echoes received by one or more receiving apertures to form high resolution ultrasound images. Additional algorithms can solve for variations in tissue speed of sound, thus allowing the ultrasound system to be used virtually anywhere in or on the body.多孔徑超音波成像系統及使用方法具有許多特徵。於一些實施例中,多孔徑超音波成像系統係組構成用以傳送超音波能量至分離之實體超音波裝置及分離之實體超音波裝置接收超音波能量。於一些實施例中,多孔徑超音波成像系統係組構成用以傳送傳送孔徑內傳送靠近第一點源之全方向未聚焦超音波波形,經過目標區域。於一些實施例中,以單一接收孔徑接收超音波能量。於其它實施例中,以多接收孔徑接收超音波能量。演算法可組合由一或更多個接收孔徑所接收之回波,以形成高解析度超音波影像。另外之演算法可解決組織音速之變化,進而允許超音波系統可實際用於肉體之內或之上之任何地方。