Zhankuic acid A, a JAK2/3 tyrosine kinase inhibitor, and a potential therapeutic agent for hepatitis

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专利权人:

National Cheng Kung University

发明人:

Tian-Shung WU,Chao-Liang WU,Ai-Li SHIAU,Yu-Fon CHEN

申请号：

US14695548

公开号：

US20150306112A1

申请日:

2015.04.24

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Zhankuic acid A (ZAA) could suppress phosphorylation of JAK2 and JAK3 and signaling of downstream molecules. Moreover, ZAA could inhibit the IFN-γ/STAT1/IRF-1 pathway in vivo and in vitro. Furthermore, data show that pre-treatment with ZAA could significantly ameliorate Con A-induced hepatitis in mice. The above results strongly suggest that ZAA treatment could block JAK2 and JAK3 activation, and may be a valuable therapeutic approach for the treatment of immune cell induced inflammation.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/