Pharmaceutical composition with anti-obesity activity of peripheral action, characterized in that it comprises a low-adhesive premix formed by: orlistat in the form of a pure, non-pelleted active ingredient, in which the content of orlistat in the premix is less than 20% by weight total mass； a diluent substance selected from the group comprising microcrystalline cellulose, powdered cellulose, modified cellulose, crosslinked carboxymethyl cellulose, calcium carboxymethyl cellulose, crospovidone, hydroxymethyl cellulose, hydroxypropyl cellulose and microcrystalline cellulose co-processing； a substance for improving the flow of the powder mixture selected from the group, comprising lactose, lactose monohydrate and co-processed lactose； a surfactant selected from the group comprising sodium lauryl sulfate and sodium docusate； a substance to promote mixing of the components of the premix selected from the group comprising colloidal silicon anhydride and hydrophobic colloidal silica； a lubricating substance selected from the group comprising sodium stearyl fumarate, magnesium stearate, calcium stearate, zinc stearate and stearic acid； a substance to facilitate the disintegration and dispersion of the components of the final pharmaceutical composition in the presence of water selected from the group comprising carboxymethyl starch, starch and modified starch； components that give the premix physical properties suitable for the simple preparation of pharmaceutical compositions for oral use, by incorporating thickening, flavoring and coloring agents into it.Composición farmacéutica con actividad antiobesidad de acción periférica, caracterizada por que comprende una premezcla de baja adhesividad formada por: orlistat en forma de un principio activo puro, no peletizado, en el que el contenido de orlistat en la premezcla es inferior al 20% del peso total de la masa； una sustancia diluyente seleccionada de entre el grupo que comprende celulosa microcristalina, celulosa en polvo
