This invention provides herbal compositions useful for increasing thetherapeutic index of drugs, including those used in the treatment of disease,especially viral infections and neoplasms of cancer. This invention providesmethods useful for improving the quality of life of an individual undergoingchemotherapy. Furthermore, this invention improves the treatment of disease byincreasing the therapeutic index of chemotherapy drugs by administering theherbal composition PHY906 to a person undergoing such chemotherapy.