Systems, methods, and devices are described for delivering treatment to a skin surface of an individual based on a microbe profile, which include a skin-treatment delivery device including at least one treatment agent reservoir with at least one port with a controllable valve, at least one conduit, a location-capture component, a data storage component to store information associated with the microbe profile, and a computing component including a processor and circuitry to receive information associated with a measured feature of a location on the skin surface, correlate the received information associated with the measured feature of the location on the skin surface with the stored information associated with the microbe profile, select one or more treatment agents for application to the location on the skin surface from a database of treatment agents, and actuate the controllable valve of the at least one treatment agent reservoir to modulate release of the selected one or more treatment agents.
