process of preparing -1- (4 - ((2- (2-aminopyrimidin-5-yl) -7-methyl-4-morpholinothieno [3,2-d] pyrimidin-6-yl) methyl) piperazin -1-yl) -2-hydroxypropan-1-one and (s) -2-hydroxy-1- (piperazin-1-yl) propan-1-one oxalate salt
FRANCIS GOSSELIN,HERBERT YAJIMA,PIRMIN HIDBER,QINGPING TIAN,REINHARD REENTS,SRINIVASAN BABU,THERESA HUMPHRIES,URSULA HOFFMANN,ZHIGANG CHENG
申请号：
BR112015007970
公开号：
BR112015007970A8
申请日:
2013.10.09
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
process of preparing -1- (4 - ((2- (2-aminopyrimidin-5-yl) -7-methyl-4-morpholinothieno [3,2-d] pyrimidin-6-yl) methyl) piperazin -1-yl) -2-hydroxypropan-1-one and (s) -2-hydroxy-1- (piperazin-1-yl) propan-1-one oxalate salt ”dual-inhibitor manufacturing process methods / pi3k gdc-0980, termed -1- (4 - ((2- (2-aminopyrimidin-5-yl) -7-methyl-4-morpholinothieno [3,2-d] pyrimidin-6-yl) methyl) piperazin-1-yl) -2-hydroxypropan-1-one, and pharmaceutically acceptable stereoisomers, geometric isomers, tautomers and salts thereof.processo de preparação de (s)-1-(4-((2-(2-aminopirimidin-5-il)- 7-metil-4-morfolinotieno[3,2-d]pirimidin-6-il)metil)piperazin-1- il)-2-hidroxipropan-1-ona e sal de oxalato de (s)-2-hidróxi-1- (piperazin-1-il)propan-1-ona” métodos de processo de fabricação de inibidor dual mtor/pi3k gdc-0980, denominado (s)-1-(4-((2-(2-aminopirimidin-5-il)-7-metil-4- morfolinotieno[3,2-d]pirimidin-6-il)metil)piperazin-1-il)-2-hidroxipropan-1-ona, e estereoisômeros, isômeros geométricos, tautômeros e sais farmaceuticamente aceitáveis destes.
