The present disclosure is directed to drug-coated balloons, particularly drug-coated balloons having a microcrystalline structure, and techniques for increasing vascular permeability for drug application and retention. Certain aspects are directed to medical devices including, for example, a balloon. The balloon has an outer surface and a drug coating layer on the outer surface of the balloon. The drug coating layer includes a plurality of microcrystals disposed on the outer surface of the balloon in an irregular and substantially non-uniform stacking orientation and / or angle. [Selection figure] None本開示は薬物被覆バルーン、特に微結晶構造を有する薬物被覆バルーンと、薬物の塗布及び保持のために血管透過性を高める技術を対象とする。特定の側面は、例えばバルーンを含む医療デバイスを対象とする。バルーンは外表面と、バルーンの外表面上の薬物被覆層とを有する。薬物被覆層は、不規則で実質的に均一性がない積わら状の配向及び／又は角度で前記バルーンの外表面に配置された複数の微結晶を含む。【選択図】なし
