Sharon M. Wahl,Nancy Vazquez-Maldonado,Teresa Greenwell-Wild
申请号：
US10578536
公开号：
US08288439B2
申请日:
2004.11.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention relates to methods and compositions for the attenuation of HIV-1 replication in human cells, and especially in human macrophages. The invention particularly concerns the use of inhibitors of P21 (CDKNIA) expression to attenuate such replication. The invention particularly concerns the use of antisense P21 oligonucleotides, siRNA and/or 2-cyano-3,12-dioxooleana-1,9-dien28-oic (CDDO) to attenuate such replication.
