SPINO, MICHAEL,HUI, ANITA,YANG, CIHUA,KABIR, MOHAMMED N.
申请号：
ES08748186
公开号：
ES2539414T3
申请日:
2008.04.25
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
An oral liquid pharmaceutical formulation comprising deferiprone from about 20 to about 200 grams per liter of the formulation and a taste masking composition, said taste masking composition comprising an effective amount of sweetener per liter of liquid formulation, wherein said Sweetener is selected from the group consisting of aspartame, saccharin, sodium saccharin, sucralose and mixtures thereof, an effective amount of a thickener and a suspension aid per liter of liquid formulation, wherein said suspension adjuvant thickener is hydroxyethyl cellulose. and wherein the amount of hydroxyethyl cellulose is about 0.5 to about 3 grams per liter of the formulation, an effective amount of a humectant per liter of liquid formulation, wherein said humectant is glycerin and in which the amount of glycerin is about 100 to about 900 grams per liter of formulation, and an effective amount of at least one flavor-conferring agent, wherein said flavor-conferring agent is selected from the group consisting of natural flavors, natural fruit flavors, artificial flavors, artificial fruit flavors, pipermin , pipermin oils and mixtures thereof, in which a final form of said oral liquid pharmaceutical formulation has a non-bitter and palatable taste.Una formulación farmacéutica líquida oral que comprende deferiprona de aproximadamente 20 a aproximadamente 200 gramos por litro de la formulación y una composición de enmascaramiento de sabor, comprendiendo dicha composición de enmascaramiento de sabor una cantidad eficaz de edulcorante por litro de formulación líquida, en la que dicho edulcorante está seleccionado entre el grupo que consiste en aspartamo, sacarina, sacarina de sodio, sucralosa y sus mezclas, una cantidad eficaz de un espesante y un coadyuvante de suspensión por litro de formulación líquida, en la que dicho agente espesante coadyuvante de suspensión es hidroxietilcelulosa y en la que la cantidad de hidroxietilcelulosa es de aproximadamente 0,5 a aproximadamente 3 gramos p
