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POLYPLEXES ANIONIQUES DESTINÉS À ÊTRE UTILISÉS POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES
专利权人:
B.G. Negev Technologies and Applications Ltd.
发明人:
申请号:
EP15751868.9
公开号:
EP3107549A4
申请日:
2015.02.19
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention provides an anionic polyplex formed from a nucleic acid and an anionic polymer and further comprising a cation, which can be in the form of a nanoparticle or a microparticle and compositions comprising the anionic polyplex. The present invention further provides uses of the anionic polyplex such as delivery of the nucleic acid into cells and methods of treating a disease, disorder or condition selected from the group consisting of cancer, a metabolic, a neurodegenerative, a cardiovascular, and an infectious or inflammatory disease or disorder. The present invention also provides an anionic complex comprising a divalent cation and a nucleic acid but lacking an anionic polymer, in the form of a nanoparticle that is capable of forming a colloidal suspension.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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