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ARNi ciblant les protéines liées au cancer
专利权人:
THE UNIVERSITY OF BRITISH COLUMBIA
发明人:
申请号:
EP10010458.7
公开号:
EP2263679B1
申请日:
2003.08.21
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
RNAi sequences that are useful as therapeutics in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease. These sequences target clusterin, IGFBP-5, IGFBP-2, both IGFBP-2 and -5 simultaneously, Mitf, and B-raf. The invention further provides for the use of these RNAi sequences in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease, and a method of treating such conditions through the administration of the RNA molecules with RNAi activity to an individual, including a human individual in need of such treatment.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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