#$%^&*AU2015202886B220160421.pdf#####ABSTRACT The present invention provides a method for maintaining the stability of an antibody in a formulation, comprising: storing an antibody formulation for six months or more at 51C or more； wherein the antibody formulation comprises: (i) about 0.1 to 100 mg/ml of a human antibody that specifically binds to human nerve growth factor (hNGF), wherein the antibody comprises a heavy chain and light chain variable region (HCVR / LCVR) amino acid sequence pairs selected from the group consisting of: (i) SEQ ID NOs: 20/22； and (ii) SEQ ID NOs: 4/12； (ii) about 0.01 to 1.0% of a polysorbate 20； (iii) about 1 to 20% of sucrose； and (iv) about 1 mM to about 50 mM acetate； whereby the stored formulation maintains stability such that 90% or more of the antibody is detected by size-exclusion high-performance liquid chromatography (SE-HPLC).
