Provided herein are compositions for inhibiting inflammation in a subject with a spinal cord injury comprising one or more agents capable of specifically reducing TNF-&alpha； signaling and a biodegradable carrier. Further provided herein are compositions for inhibiting inflammation in a subject with a spinal cord injury comprising one or more agents capable of modulating MCP-1 signaling and a biodegradable carrier. Methods of treating inflammation in a subject having a spinal cord injury and kits for producing the compositions are also disclosed.
