CITY OF HOPE;UNIVERSITY OF CHICAGO;UNIVERSITY OF ALABAMA AT BIRMINGHAM
发明人:
Karen S. ABOODY,Alexander J. ANNALA,David CURIEL,Maciej LESNIAK
申请号：
US16361100
公开号：
US20190275093A1
申请日:
2019.03.21
申请国别(地区):
US
年份:
2019
代理人:
摘要：
In some embodiments, methods of killing tumor cells are provided. The methods may include contacting the tumor cell with a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective element and/or a capsid protein that binds a tumor-specific cell surface molecule. In another embodiment, methods of treating cancer are provided. The methods may include administering a therapeutically effective amount of a pharmaceutical composition to a subject, wherein the pharmaceutical composition includes a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective promoter element and/or a capsid protein that binds a tumor-specific cell surface molecule.
