An evacuation system and method for removing and/or treating gaseous and/or particulate byproducts of surgical procedures includes an end effector such as a side vent trocar, an operating room tower or the equivalent, a disposal vessel, a vacuum source and optionally a filter. The end effector may be coupled to the tower by a conduit, the tower may be coupled to the collection tank by a conduit, and the collection tank may be coupled to the vacuum source. Gaseous and/or particulate byproducts may flow from the surgical site through the trocar, conduits, tower tank and filter, and the flow may be regulated at least in part by the components of the system.