The present disclosure provides,inter alia, pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. In certain embodiments, the pharmaceutical compositions contain nonabsorbable compositions and may be used, for example, to treat diseases or other metabolic conditions in which removal of protons, the conjugate base of a strong acid and/or a strong acid from the gastrointestinal tract would provide physiological benefits such as normalizing serum bicarbonate concentrations and the blood pH in an animal, including a human. In certain embodiments, compositions for and methods of improving the quality of life and/or physical function score of such patients are also provided. In certain embodiments, compositions for and methods of slowing the progression of kidney disease in such patients are also provided.本揭示提供尤其用於治療動物(包括人類)之醫藥組合物及方法，以及製備此類組合物之方法。在某些實施例中，該等醫藥組合物含有不可吸收組合物且可用於例如治療疾病或其他代謝病狀，其中自胃腸道中移除質子、強酸之共軛鹼及/或強酸將提供生理益處，諸如正常化動物(包括人類)的血清碳酸氫鹽濃度及血液pH。在某些實施例中，亦提供用於改善此類患者之生活品質及/或身體功能(physical function)分數之組合物及方法。在某些實施例中，亦提供減緩此類患者之腎病進展之組合物及方法。
