#$%^&*AU2015238897A120151029.pdf#####ABSTRACT The present invention provides pyrimidinones that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PJ3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.FIG. 1 I /2