Christopher J. Murray,Pilar Tijerina,David A. Estell,Yiyou Chen
申请号：
US13658713
公开号：
US08779091B2
申请日:
2012.10.23
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A selective targeting method is disclosed comprising contacting a library of ligands, particularly a peptide library, with an anti-target to allow the ligands to bind to the anti-target； separating the non-binding ligands from the anti-target bound ligands, contacting the non-binding anti-target ligands with a target allowing the unbound ligands to bind with the target to form a target-bound ligand complex； separating the target-bound ligand complex from ligands which do not bind to the target, and identifying the target-bound ligands on the target-bound ligand complex wherein the target-bound ligands have a KD in the range of about 10−7 to 10−10 M. Additionally claimed are the ligands identified according to the method.
