BISPECIFIC ANTIBODY BINDING TO AGR2 PROTEIN AND CHI3L1 PROTEIN, CONSTRUCTION, EXPRESSION, PURIFICATION METHOD THEREFOR, AND USE THEREOF

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专利权人:

Shanghai Jiao Tong University;Shenzhen Hubio Biotechnology Co. LTD

发明人:

Li, Dawei,Wang, Zeling

申请号：

AU2020101779

公开号：

AU2020101779A4

申请日:

2020.08.12

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

#$%^&*AU2020101779A420200917.pdf#####Abstract of the Disclosure The present invention provides a bispecific antibody having a function of binding to AGR2 protein and CHI3L1 protein, the bispecific antibody includes an anti-AGR2 antibody 18A4Hu as a parent structure, and an anti-CHI3L1 antibody FRGscFv fragment connected to a C-terminus of a light chain of the anti-AGR2 antibody 18A4Hu. The present invention provides also provides construction, expression, purification method for a bispecific antibody having a function of binding to AGR2 protein and CHI3L1 protein, and use of the bispecific antibody in the field of medicine and especially in the treatment of cancer.

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http://www.ckcest.cn/home/