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PHENYLAMINOPYRIMIDINES SUBSTITUEES
专利权人:
BAYER HEALTHCARE AG
发明人:
SCHIROK, HARTMUT,STASCH, JOHANNES-PETER,KAST, RAIMUND,MUENTER, KLAUS,GNOTH, MARK JEAN,FIGUEROA PEREZ, SANTIAGO,THUTEWOHL, MICHAEL,BENNABI, SAMIR,LANG, DIETER,MITTENDORF, JOACHIM,RADTKE, MARTIN,EHMKE,
申请号:
CA2564629
公开号:
CA2564629C
申请日:
2005.04.14
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
The invention relates to a compound of formula (I), to process for itspreparation andto its use for preparing a medicament for the treatment of a disease, such asacardiovascular disorder, wherein the compound is:(see formula I)or one of its salts, its solvates or the solvates of its salts, wherein -----is a single ordouble bond; X is -NR6-' -CR7R8- or -C(=O)-, wherein R6, R7 and R8 are H oralkyl;R1 is H, halogen or cyano, or optionally substituted (C1-C6)-alkyl, (C3-C6)-cycloalkyl,(C1-C6)-alkoxycarbonyl or (C1-C6)-alkylaminocarbonyl; R2 is F or Cl; R3 is H,OH,halogen, trifluoromethyl or pentafluoroethyl; or optionally substituted (C1-C6)-alkyl,(C1-C6)-alkoxy or (C3-C8)-cycloalkyl; or optionally substituted (C6-C10)-aryl,(C6-C10)--aryloxy or 5- to 10-membered heteroaryl, heteroaryloxy orheterocyclyl; or -NR11R12,wherein R11 and R12 are optionally substituted (C1-C6)-alkyl or (C3-C8)-cycloalkyl, orH, (C6-C10)-aryl or 5- to 10-membered heteroaryl; or R11 and R12 together formanoptionally substituted 4- to 6-membered heterocycle; or R11 and R12 togetherform anoptionally substituted 7- to 12-membered bicyclic or tricyclic heterocycle; or-C(=O)R19, wherein R19 is (C1-C6)-alkoxy, optionally substituted (C1-C6)-alkylamino ora 5- to 10-membered mono- or bicyclic heterocycle; R4 is H, F or Cl; and R5 isH or(C1-C6)-alkyl.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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