The surface active agent and the appropriate carrier solvent are included metahurumizon, the building a bridge medicine (according to need), the high filling up concentrated composition. Although these compositions section are prescribed by the animal and prevent or deal with outside in profit and the endotherm outside parasitism of the parasite over the long period of time, it is useful. In addition, these compositions, furthermore being diluted, can offer active other prescription ones to local dosage and to oral administration. This invention, being the high filling up concentrated composition for local dosage, in the weight anti- capacity base, approximately 5% - approximately 25% metahurumizon, approximately 0% - approximately 15% building a bridge medicine, approximately offers 2% - approximately 15% surface active agent, and approximately the composition which includes 50% - approximately 80% carrier solvent.メタフルミゾン、架橋剤(必要に応じて)、界面活性剤および適切なキャリア溶媒を含む、高充填濃縮組成物。これらの組成物は、動物に局所投与され得、温血動物における外部寄生虫の外寄生を長期間にわたり予防または処置するのに有用である。また、これらの組成物は、更に希釈されて、局所投与にも経口投与にも使用可能な他の処方物を提供し得る。本発明は、局所投与用の高充填濃縮組成物であって、重量対容量ベースで、約5%~約25%のメタフルミゾン、約0%~約15%の架橋剤、約2%~約15%の界面活性剤、および約50%~約80%のキャリア溶媒を含む組成物を提供する。