UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
发明人:
CHOUNG, Se-Young,정세영,CHOI, Yeung Joon,최영준
申请号：
KRKR2013/007598
公开号：
WO2014/030977A1
申请日:
2013.08.23
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The present invention relates to peptides which are separated from the fractions of oyster enzyme hydrolysate and which exhibit inhibitory activity against angiotensin-converting enzyme (ACE), and to a pharmaceutical composition comprising the peptides as active ingredients for preventing or treating cardiovascular diseases. More particularly, the peptides of the present invention separated from the fractions of oyster enzyme hydrolysate may significantly inhibit the activity of ACE, and may exhibit the effects of blood pressure regulation and hypertension prevention. Therefore, the fractions of oyster enzyme hydrolysate or peptides separated therefrom can be effectively used as active ingredients for a pharmaceutical composition for preventing or treating cardiovascular diseases.La présente invention concerne des peptides séparés de fractions dhydrolysat denzyme dhuître, qui présentent une activité inhibitrice contre lenzyme de conversion de langiotensine (ECA). Linvention porte en outre sur une composition pharmaceutique comprenant lesdits peptides en tant que principes actifs dans la prévention ou le traitement de maladies cardiovasculaires. Plus particulièrement, les peptides selon la présente invention séparés des fractions dhydrolysat denzyme dhuître permettent dinhiber significativement lactivité de lECA, et peuvent présenter des effets en termes de régulation de la tension artérielle et de prévention de lhypertension. Ainsi, les fractions dhydrolysat denzyme dhuître ou les peptides séparés de ces dernières peuvent être utilisés efficacement en tant que principes actifs pour une composition pharmaceutique dans la prévention ou le traitement de maladies cardiovasculaires.본 발명은 굴 효소 가수분해물(oyster enzyme hydrate)의 분획물로부터 분리된 안지오텐신 전환 효소(angiotensin converting enzyme ACE)에 대해 저해능을 나타내는 펩타이드 및 상기 펩타이드를 유효성분으로 포함하는 심혈관계 질환 예방 또는 치료용 약학적 조성물에 관한 것으로, 구체적으로 본 발명의 굴 효소 가수분해물의 분획물로부터 분리된 펩타이드는 ACE 활성을 유의적으로 저해하며, 효과적인 혈압 조절 효과 및 고혈압 예방 효과를 나타내므로, 상기 굴 효소 가수분해물의 분획물 또는 이
