Devices (20) for delivering and deploying a prosthesis are disclosed and comprise a sheath (50), a prosthesis (26) disposed within a distal end portion of the sheath, and a wire (72) having a first end coupled to the prosthesis and a second end coupled to the sheath. A body portion of the wire comprises a slack in the wire, and the sheath, prosthesis, and wire are configured so that a proximal movement of the sheath relative to the prosthesis reduces the slack in the wire, and a subsequent proximal movement of the sheath relative to the prosthesis decouples the wire from the prosthesis. Additional devices, systems, and methods are disclosed.