A medical device case for allowing passage of a tube from the interior to the exterior of a case such that the case is sealed against fluid intrusion whether a tube is present or absent. The medical device case generally includes a case having a first portion and a second portion hingedly connected to the first portion. The first portion and second portion may be closed together to define a compartment in which a medical device may be positioned. A tube seal assembly is included which will allow a tube leading from the medical device within the compartment to exit the case through a passage. The tube seal assembly generally includes a first seal and second seal which combine when the case is closed to seal around the tube when it is present or to seal against each other when no tube is present.
