Stephen Lewis Hart,Stephanie Grosse,Alethea Bernice Tabor,John Bosco Wong,Martin Elbs,Helen Claire Hailes,Mohd Firouz Mohd Mustapa
申请号：
US12227735
公开号：
US09399016B2
申请日:
2007.05.30
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention provides a peptide derivative of formula A-B-C whereinA is a polycationic nucleic acid-binding componentB is a spacer element peptide that is susceptible to cleavage within a cell andC is a cell surface receptor binding component.The invention also provides a lipid derivative of general formula (I):(PEG)q-Linker-Spacer-Cationic headgroup-carbon skeleton-(hydrophobic chain)o wherein:the Linker is a group susceptible to cleavage within a cellthe Spacer is a group linking the Linker to the Cationic headgroupq denotes the number of PEG chains and q=1, 2 or 3o denotes the number of hydrophobic chains and o=1, 2 or 3the carbon skeleton is a group linking the hydrophobic chains to the cationic headgroup.The peptide and lipid derivatives find use in non-viral gene delivery systems.
